Potential of Plant Bioactive Compounds for the Treatment of Cancer:  Bioactive Compounds for the Treatment of Cancer

Hammad Ahmed Abbasi; Muhammad Atif; Muhammad Naveed Anjum; Jawad Ahmed; Abdul Wahab; Syed Ashman Ali Shah

doi:10.54393/fbt.v5i2.177

Authors

Hammad Ahmed Abbasi Department Molecular Biology and Genetics, Erzurum Technical University, Turkey
Muhammad Atif Center of Applied Molecular Biology, University of the Punjab, Lahore, Pakistan
Muhammad Naveed Anjum Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
Jawad Ahmed Department of Botany, University of Agriculture, Peshawar, Pakistan
Abdul Wahab Institute of Kidney Diseases, Peshawar, Pakistan
Syed Ashman Ali Shah Center of Biotechnology and Microbiology, University of Peshawar, Pakistan

DOI:

https://doi.org/10.54393/fbt.v5i2.177

Keywords:

Alkaloids, MAPK Signaling, Apoptosis, Phytochemicals, Oncogenic Pathways

Abstract

Cancer remains one of the leading causes of mortality worldwide. Despite recent advances, current chemotherapeutic options often have undesirable side effects, and the development of resistance limits their long-term effectiveness. The botanical kingdom contains a vast repository of phytochemicals with varying biological activities. This review examines the anticancer potential of various classes of plant bioactive compounds. Specific alkaloids like berberine demonstrate remarkable apoptosis induction through mitochondrial stress and caspase activation in numerous cancer cell lines. Curcumin modulates multiple oncogenic pathways, including PI3K/Akt, Wnt/β-catenin, and MAPK signaling. Resveratrol elicits favorable anti-tumor responses through intrinsic apoptosis, autophagy stimulation, and antiangiogenic effects. Promising preclinical studies have elucidated the underlying molecular mechanisms by which bioactive components such as quercetin, genistein, and epigallocatechin gallate exert chemopreventive effects. While intensive research is still required, progress in standardizing extracts, isolating marker compounds, and clinical testing validates nature's treasure as a source for novel anticancer options. Future studies should focus on overcoming translational barriers to move these promising compounds from bench to bedside.

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