Overview of Marburg Viral Disease: Marburg Viral Disease

Rameen Atique; Hafiza Arshi Saeed; Hafeez Ur Rehman Ali Khera; Areesha Naveed; Javeria Sharif; Hafiza Rida Fatima; Ayesha Haidar; Aqsa Perveen; Abdul Samad

doi:10.54393/fbt.v5i1.82

Authors

Rameen Atique Department of Pathobiology and Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Hafiza Arshi Saeed Department of Pathobiology and Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Hafeez Ur Rehman Ali Khera Department of Clinical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Areesha Naveed Department of Pathobiology and Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Javeria Sharif Department of Pathobiology and Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Hafiza Rida Fatima Department of Pathobiology and Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Ayesha Haidar Department of Pathobiology and Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Aqsa Perveen Department of Pathobiology and Biomedical Sciences, Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
Abdul Samad Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju 52828, Korea

DOI:

https://doi.org/10.54393/fbt.v5i1.82

Keywords:

Marburg Virus, Bats, Fruit Bats, Enzyme-Linked Immunosorbent Assay, Polymerase Chain Reaction

Abstract

Marburg viral disease induced by the Marburg virus. It is a constituent of the Filovirus family, which also encloses the Ebola virus. The disease first came into light in 1967 during episodes of the virus in Marburg and Germany. After that, the infection caused high CFR in Angola, Uganda, and Congo. The disease includes the sudden outset of symptoms, including high fever, vomiting, intense headache, abdominal pain, and rash. In patients with severe infection, it leads to bleeding, jaundice, organ collapse, and eventually death. Fruit bats of genus Rousettus are considered to be the biological pool of the Marburg virus. This disease destroyed African countries with high death rates. The virus can be transferred from green African monkeys or fruit bats. It can be transmitted through human-to-human interactions via blood, body fluids of diseased people, and contaminated surfaces. MVD can be diagnosed by technical laboratory tests incorporating enzyme-linked immunosorbent assay (ELISA), reverse transcription-polymerase chain reaction (RT-PCR), and virus seclusion. Supportive maintenance has been done to demonstrate some efficacy in controlling the symptoms and improving the probability of survival. Adequate management and care have been taken to prevent the unusual spread of disease, such as the separateness of infected patients and suspected individuals, which should pertain to quarantine measures. Because of the high casualty rate and lack of a certified vaccine or any antiviral cure, the only way to keep MVD in check can be through prevention. This review briefly overviews the Marburg virus, including diagnosis, pathogenesis, transmission, and treatment.

References

Brauburger K, Hume AJ, Mühlberger E, Olejnik J. Forty-five years of Marburg virus research. Viruses. 2012 Oct; 4(10): 1878-927. doi: 10.3390/v4101878.

Ristanović ES, Kokoškov NS, Crozier I, Kuhn JH, Gligić AS. A forgotten episode of Marburg virus disease: Belgrade, Yugoslavia, 1967. Microbiology and Molecular Biology Reviews. 2020 May; 84(2): 10-128. doi: 10.1128/MMBR.00095-19.

Abir MH, Rahman T, Das A, Etu SN, Nafiz IH, Rakib A et al. Pathogenicity and virulence of Marburg virus. Virulence. 2022 Dec; 13(1): 609-33. doi: 10.1080/21505594.2022.2054760.

Thomas B, Chandran P, Lilabi MP, George B, Sivakumar CP, Jayadev VK et al. Nipah virus infection in Kozhikode, Kerala, South India, in 2018: epidemiology of an outbreak of an emerging disease. Indian Journal of Community Medicine. 2019 Oct; 44(4): 383-7. doi: 10.4103/ijcm.IJCM_198_19.

Blair PW, Keshtkar-Jahromi M, Psoter KJ, Reisler RB, Warren TK, Johnston SC et al. Virulence of marburg virus Angola compared to Mt. Elgon (Musoke) in macaques: A pooled survival analysis. Viruses. 2018 Nov; 10(11): 658. doi: 10.3390/v10110658.

Nicholas VV, Rosenke R, Feldmann F, Long D, Thomas T, Scott DP et al. Distinct biological phenotypes of Marburg and Ravn virus infection in macaques. The Journal of Infectious Diseases. 2018 Nov; 218(suppl_5): S458-65. doi: 10.1093/infdis/jiy456.

Muvunyi CM, Ngabonziza JC, Bigirimana N, Ndembi N, Siddig EE, Kaseya J et al. Evidence-Based Guidance for One Health Preparedness, Prevention, and Response Strategies to Marburg Virus Disease Outbreaks. Diseases. 2024 Dec; 12(12): 309. doi: 10.3390/diseases12120309.

Bausch DG, Nichol ST, Muyembe-Tamfum JJ, Borchert M, Rollin PE, Sleurs H et al. Marburg hemorrhagic fever associated with multiple genetic lineages of virus. New England Journal of Medicine. 2006 Aug; 355(9): 909-19. doi: 10.1056/NEJMoa051465.

Qiu X, Wong G, Audet J, Cutts T, Niu Y, Booth S et al. Establishment and characterization of a lethal mouse model for the Angola strain of Marburg virus. Journal of Virology. 2014 Nov; 88(21): 12703-14. doi: 10.1128/JVI.01643-14.

Bertherat E, Talarmin A, Zeller H. Democratic Republic of the Congo: between civil war and the Marburg virus. International Committee of Technical and Scientific Coordination of the Durba Epidemic. Medecine Tropicale: Revue du Corps de Sante Colonial. 1999 Jan; 59(2): 201-4.

Towner JS, Amman BR, Sealy TK, Carroll SA, Comer JA, Kemp A et al. Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLOS Pathogens. 2009 Jul; 5(7): e1000536. doi: 10.1371/journal.ppat.1000536.

Miraglia CM. Marburgviruses: an update. Laboratory Medicine. 2019 Jan; 50(1): 16-28. doi: 10.1093/labmed/lmy046.

Emond RT, Evans B, Bowen ET, Lloyd G. A case of Ebola virus infection. British Medical Journal. 1977 Aug; 2(6086): 541-4. doi: 10.1136/bmj.2.6086.541.

Dye JM, Herbert AS, Kuehne AI, Barth JF, Muhammad MA, Zak SE et al. Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease. Proceedings of the National Academy of Sciences. 2012 Mar; 109(13): 5034-9. doi: 10.1073/pnas.1200409109.

Srivastava S, Sharma D, Kumar S, Sharma A, Rijal R, Asija A et al. Emergence of Marburg virus: a global perspective on fatal outbreaks and clinical challenges. Frontiers in Microbiology. 2023 Sep; 14: 1239079. doi: 10.3389/fmicb.2023.1239079.

Islam MA, Adeiza SS, Amin MR, Kaifa FH, Lorenzo JM, Bhattacharya P et al. A bibliometric study on Marburg virus research with prevention and control strategies. Frontiers in Tropical Diseases. 2023 Jan; 3: 1068364. doi: 10.3389/fitd.2022.1068364.

Chakraborty S, Chandran D, Mohapatra RK, Alagawany M, Yatoo MI, Islam MA et al. Marburg virus disease-a mini-review. 2022 Aug; 10(4).

Albakri K, Al-Hajali M, Saleh O, Alkhalil AM, Mohd AB, Samain CA et al. Marburg virus disease treatments and vaccines: recent gaps and implications. Annals of Medicine and Surgery. 2023 Feb; 85(2): 328-30. doi: 10.1097/MS9.0000000000000163.

Lawrence JA, Ul Rasool MH, Parikh C, Chowdhury S, Sueldo A, Sarwar S. Emergence of Marburg virus disease in West Africa amid COVID-19 and Ebola: efforts, challenges, and recommendations to prevent the next public health crisis. Journal of Infectiology and Epidemiology. 2022 Apr; 8: 259. doi: 10.23937/2474-3658/1510259.

Prator CA, Dorratt BM, O'Donnell KL, Lack J, Pinski AN, Ricklefs S et al. Transcriptional profiling of immune responses in NHPs after low-dose, VSV-based vaccination against Marburg virus. Emerging Microbes & Infections. 2023 Dec; 12(2): 2252513. doi: 10.1080/22221751.2023.2252513.

Saijo M, Niikura M, Ikegami T, Kurane I, Kurata T, Morikawa S. Laboratory diagnostic systems for Ebola and Marburg hemorrhagic fevers developed with recombinant proteins. Clinical and Vaccine Immunology. 2006 Apr; 13(4): 444-51. doi: 10.1128/CVI.13.4.444-451.2006.

Elsheikh R, Makram AM, Selim H, Nguyen D, Le TT, Tran VP et al. Reemergence of Marburgvirus disease: update on current control and prevention measures and review of the literature. Reviews in Medical Virology. 2023 Sep; 33(5): e2461. doi: 10.1002/rmv.2461.

Koundouno FR, Kafetzopoulou LE, Faye M, Renevey A, Soropogui B, Ifono K et al. Detection of Marburg virus disease in Guinea. New England Journal of Medicine. 2022 Jun; 386(26): 2528-30. doi: 10.1056/NEJMc2120183.

Zhu W, Zhang Z, He S, Wong G, Banadyga L, Qiu X. Successful treatment of Marburg virus with orally administrated T-705 (Favipiravir) in a mouse model. Antiviral Research. 2018 Mar; 151: 39-49. doi: 10.1016/j.antiviral.2018.01.011.

Daddario-DiCaprio KM, Geisbert TW, Ströher U, Geisbert JB, Grolla A, Fritz EA et al. Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment. The Lancet. 2006 Apr; 367(9520): 1399-404. doi: 10.1016/S0140-6736(06)68546-2.

Kortepeter MG, Dierberg K, Shenoy ES, Cieslak TJ. Marburg virus disease: a summary for clinicians. International Journal of Infectious Diseases. 2020 Oct; 99: 233-42. doi: 10.1016/j.ijid.2020.07.042.

Paragas J and Geisbert TW. Development of treatment strategies to combat Ebola and Marburg viruses. Expert Review of Anti-Infective Therapy. 2006 Feb; 4(1): 67-76. doi: 10.1586/14787210.4.1.67.

Zhao F, He Y, Lu H. Marburg virus disease: a deadly rare virus is coming. Bioscience Trends. 2022 Aug; 16(4): 312-6. doi: 10.5582/bst.2022.01333.

Iversen PL, Warren TK, Wells JB, Garza NL, Mourich DV, Welch LS et al. Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections. Viruses. 2012 Nov; 4(11): 2806-30. doi: 10.3390/v4112806.

Thi EP, Mire CE, Ursic-Bedoya R, Geisbert JB, H. Lee AC, Agans KN et al. Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA. Science Translational Medicine. 2014 Aug; 6(250): 250ra116-. doi: 10.1126/scitranslmed.3009706.

Cross RW, Fenton KA, Geisbert JB, Ebihara H, Mire CE, Geisbert TW. Comparison of the pathogenesis of the Angola and Ravn strains of Marburg virus in the outbred guinea pig model. The Journal of Infectious Diseases. 2015 Oct; 212(suppl_2): S258-70. doi: 10.1093/infdis/jiv182.

Zhang L, Lei S, Xie H, Li Q, Liu S, Liu Q et al. Screening and identification of Marburg virus entry inhibitors using approved drugs. Virologica Sinica. 2020 Apr; 35: 235-9. doi: 10.1007/s12250-019-00184-3.

Marzi A, Feldmann H, Geisbert TW, Falzarano D. Vesicular stomatitis virus-based vaccines for prophylaxis and treatment of filovirus infections. Journal of Bioterrorism & Biodefense. 2011 Sep; 9(4). doi: 10.4172/2157-2526.S1-004.

Cheng K, Guo Q, Gu S, Wu H, Li C. Deadly Marburg virus outbreak received sustained attention: What can we learn from the existing studies?. International Journal of Surgery. 2023 Aug; 109(8): 2539-41. doi: 10.1097/JS9.0000000000000443.

Zumbrun EE, Garvey CB, Wells JB, Lynn GC, Van Tongeren S, Steffens JT et al. Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing. Viruses. 2023 Nov; 15(12): 2335. doi: 10.3390/v15122335.

Cheng H, Lear-Rooney CM, Johansen L, Varhegyi E, Chen ZW, Olinger GG et al. Inhibition of Ebola and Marburg virus entry by G protein-coupled receptor antagonists. Journal of Virology. 2015 Oct; 89(19): 9932-8. doi: 10.1128/JVI.01337-15.

Valmas C, Grosch MN, Schümann M, Olejnik J, Martinez O, Best SM et al. Marburg virus evades interferon responses by a mechanism distinct from ebola virus. PLOS Pathogens. 2010 Jan; 6(1): e1000721. doi: 10.1371/journal.ppat.1000721.

Hartman AL, Towner JS, Nichol ST. Ebola and marburg hemorrhagic fever. Clinics in Laboratory Medicine. 2010 Mar; 30(1): 161-77. doi: 10.1016/j.cll.2009.12.001.

Simpson DI and World Health Organization. Marburg and Ebola virus infections: a guide for their diagnosis, management and control. World Health Organization; 1977.

Maideen NM. A review of inherent beneficial effects of black seeds (Nigella sativa) in Marburg virus disease management. Food Health. 2023; 5(6). doi: 10.53388/FH2023006.