Syzygium cumini-mediated Green Synthesis of Magnesium Oxide Nanoparticles and Evaluation of their Antibacterial, Antileishmanial, and Antioxidant Activities

Syzygium cumini-mediated Green Synthesis of Magnesium Oxide Nanoparticles

Authors

  • Suliman Syed Institute of Biotechnology and Microbiology, Bacha Khan University, Charsadda, Pakistan
  • Arshad Islam Department of Pathology, Government Lady Reading Hospital Medical Teaching Institution, Peshawar, Pakistan
  • Ajmal Khan Institute of Biotechnology and Microbiology, Bacha Khan University, Charsadda, Pakistan
  • Iftikhar Ahmad Institute of Biotechnology and Microbiology, Bacha Khan University, Charsadda, Pakistan
  • Tahir Salam Institute of Biotechnology and Microbiology, Bacha Khan University, Charsadda, Pakistan
  • Nadia Irfan Department of Biotechnology, Abdul Wali Khan University, Mardan, Pakistan

DOI:

https://doi.org/10.54393/fbt.v4i01.63

Keywords:

Magnesium Oxide Nanoparticles, Syzygium cumini, Antibacterial, Antileishmanial, Antioxidant

Abstract

Green protocols for the synthesis of nanoparticles have gained significant attention due to their environmental friendliness, ease, and cost-effectiveness. The present study focused on the synthesis of magnesium oxide nanoparticles (MgO-NPs) using an aqueous leaves extract of   Syzygium cumini plant, and the antimicrobial potential of the synthesized NPs. Methods: The synthesis of MgO-NPs was achieved by mixing a solution of magnesium nitrate (Mg (NO3)2 with an aqueous extract obtained from S. cumini leaves to reduce the Mg+ ions. These NPs were characterized by X-ray diffraction (XRD), Fourier-Transform Infrared (FTIR) Spectroscopy analysis, Scanning electron microscopy (SEM), and Energy-dispersive X-ray (EDX) analysis. Results: The transformation in color of the solution from yellow to deep brown along with the UV absorption peak at 294 nm showed the effective synthesis of MgO-NPs. SEM and XRD data revealed cubic-shaped NPs with an average size of 23.73 nm. EDX analysis confirmed the presence of magnesium and oxygen in the sample at 31.85% and 35.11% weight percentages, respectively. The antibacterial evaluation demonstrated effectiveness against the gram-negative strains Citrobacter koseri and Pseudomonas aeruginosa, with inhibition zones of 28.1 ± 1.25 mm and 27.8 ± 1.25 mm, respectively. MgO-NPs also showed antileishmanial potential against Leishmania tropica promastigotes (68.41 ± 0.05% inhibition at 1000µg/ml). Furthermore, the NPs exhibited antioxidant properties (75.12 ± 4.29% at 1 mg/ml) as determined by the DPPH radical scavenging assay. Conclusions: MgO-NPs synthesized using S. cumini plant leaves extract hold promises as agents for antibacterial, antileishmanial, and antioxidant applications. 

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Published

2024-03-31
CITATION
DOI: 10.54393/fbt.v4i01.63
Published: 2024-03-31

How to Cite

Syed, S., Islam, A., Khan, A., Ahmad, I., Salam, T., & Irfan, N. (2024). Syzygium cumini-mediated Green Synthesis of Magnesium Oxide Nanoparticles and Evaluation of their Antibacterial, Antileishmanial, and Antioxidant Activities : Syzygium cumini-mediated Green Synthesis of Magnesium Oxide Nanoparticles. Futuristic Biotechnology, 4(01), 36–42. https://doi.org/10.54393/fbt.v4i01.63

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