Physiological Effects of Alloxan on Serum Glucose Levels and Liver Function Test in Male Rabbit: Physiological Effects of Alloxan on Serum Glucose Levels

Iftikhar Ahmed Pirzada; Allah Bux Kachiwal; Jameela Soomro; Rhahana S Buriro

doi:10.54393/fbt.v4i02.121

Authors

Iftikhar Ahmed Pirzada Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan
Allah Bux Kachiwal Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan
Jameela Soomro Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan
Rhahana S Buriro Department of Veterinary Pharmacology, Sindh Agriculture University, Tandojam, Pakistan

DOI:

https://doi.org/10.54393/fbt.v4i02.121

Keywords:

Alloxan, Glucose, Liver Function Test, Insulin, Physiological Effect, Rabbit

Abstract

Diabetes is a metabolic disorder characterized by elevated blood glucose levels that can lead to various complications. Exploring the physiological alterations in rabbits can provide valuable insights for the development of therapeutic interventions. This research delves into the impact of diabetes on the physiological and biochemical parameters of male rabbits. Objectives: To compare the physiological parameters like body temperature, heart rate, respiration rate, and oxygen saturation) and body weight and biochemical parameters, including blood glucose levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, lactate dehydrogenase (LDH), and total protein levels in diabetic and non-diabetic rabbits. Methods: An experiment on 30 male rabbits divided into diabetic and control groups measured physiological parameters like body temperature, heart rate, respiration rate, and oxygen saturation. Body weight and blood glucose levels were tracked, and blood samples were taken for ALT, AST, creatinine, LDH, cholesterol, triglycerides and total protein levels. Statistical analysis was conducted to compare the physiological and biochemical parameters between the diabetic and control groups. Results: The results showed that induced diabetes in male rabbits affects their physiological and biochemical parameters significantly. Diabetic rabbits had lower body temperature, heart rate, respiration rate, and oxygen saturation compared to the control group. They also had higher body weight and blood glucose levels. Biochemical analysis showed increased ALT, AST, and creatinine levels, and decreased LDH and total protein levels in diabetic rabbits. Conclusions: These results demonstrate the extensive impact of diabetes on rabbit physiology and biochemistry, offering insights for future diabetes research.

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