Effect of β-Galacto-Oligosaccharides on Growth Performance in Physiologically Stressed Rabbits: β-Galacto-Oligosaccharides on Growth Performance in Stressed Rabbits

Jameel Ahmed Shaikh; Allah Bux Kachiwal; Saeed Ahmed Soomro; Gulfam Ali Mughal; Tahseen Jamil Shaikh

doi:10.54393/fbt.v5i1.110

Authors

Jameel Ahmed Shaikh Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan
Allah Bux Kachiwal Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan
Saeed Ahmed Soomro Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan
Gulfam Ali Mughal Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan
Tahseen Jamil Shaikh Department of Veterinary Physiology and Biochemistry, Sindh Agriculture University, Tandojam, Pakistan

DOI:

https://doi.org/10.54393/fbt.v5i1.110

Keywords:

Growth Performance, Weight Gain, Stress in Rabbits, Hepatic Function

Abstract

Growth performance analysis under this study evaluated the dietary impact of β-galacto-oligosaccharides (β-GOS). Scientists have established that prebiotic β-GOS promotes health in the gut tissue, thus leading to enhanced productivity alongside improved general health during dexamethasone-induced stress conditions. Objectives: To investigate whether the addition of β-GOS to rabbit diets would positively affect their physiology-linked weight gain as well as their feed efficiency and developmental metrics. Methods: A 12-week experiment with 40 rabbits belonging to 3 ± 0.98 months of age and weighing 1.48 ± 0.41 kg allocated 8 animals to each dietary treatment group. Among all monitored aspects, live body weight and food intake, and feed conversion efficiency (FCR) were ranked as significant items. Rabbits received feed consumption measurements each day and underwent body weight assessment every week. Results: Feeding rabbits β-GOS under stress greatly improved their health and growth performance. Compared to Groups A-D, Group E (D-S15 + 0.3% β-GOS) had the greatest FCR and the largest gain in live body weight. The group that consumed the most feed was Group A (Negative Control). Group E. Conclusions showed the most efficient feed conversion. Conclusions: It was concluded that supplementing stressed rabbits with β-GOS can successfully increase their growth, feed conversion efficiency, and general health, providing a useful dietary strategy to alleviate growing deficits caused by stress.

References

Siddiqui SA, Gerini F, Ikram A, Saeed F, Feng X, Chen Y. Rabbit Meat—Production, Consumption and Consumers’ Attitudes and Behavior. Sustainability. 2023 Jan; 15(3): 2008. doi: 10.3390/su15032008.

Wu L. Worldwide Rabbit Meat Trade. In Veterinary Care of Farm Rabbits: A Complete Practice Guide to Rabbit Medicine and Production. Cham: Springer International Publishing. 2024 May: 67-92. doi: 10.1007/978-3-031-44542-2_4.

Shaikh JA, Kachiwal AB, Soomro SA, Mughal GA. Evaluation of the Influence of Β-Galacto-Oligosaccharides On Hepatic Functions and Blood Metabolites in Physiologically Stressed Rabbits. International Journal of Stress Management. 2024; 31 (4): 127-160.

Khan FA, Kachiwal AB, Khaliq J, Soomro SA, Ahmad T, Khan MB et al. Effect of Supplementation of B-Galacto-Oligosaccharide And Probiotic Mixture On Growth Performance Of Physiologically Stressed Rabbits. Journal of Advanced Zoology. 2024 Dec; 45(6): 311-321. doi: 10.53555/jaz.v45i6.5023.

Abd El-Aziz A, Aboghanima M, Kamel S, El-Deeb E, Mahrous UE. Influence of Two Dietary Prebiotic Oligosaccharides Supplementation On Productive Performance and Carcass Traits with Special Attention to Their Biochemical Alterations in Two Rabbit Breeds. Damanhour Journal of Veterinary Sciences. 2020 Jan; 3(1): 1-7. doi: 10.21608/djvs.2019.19337.1005.

Hu Y, Aljumaah MR, Azcarate-Peril MA. Galacto-Oligosaccharides and the Elderly Gut: Implications for Immune Restoration and Health. Advances in Nutrition. 2024 Aug; 15(8): 100263. doi: 10.1016/j.advnut.2024.100263.

Mei Z, Yuan J, Li D. Biological Activity of Galacto-Oligosaccharides: A review. Frontiers in Microbiology. 2022 Sep; 13: 993052. doi: 10.3389/fmicb.2022.993052.

Ahmad S, Yousaf MS, Tahir SK, Rashid MA, Majeed KA, Naseem M et al. Effects of Co-Supplementation of β-Galacto-Oligosaccharides and Methionine on Breast Meat Quality, Meat Oxidative Stability and Selected Meat Quality Genes in Broilers. Pakistan Veterinary Journal. 2023 Jul; 43(3). doi: 10.29261/pakvetj/2023.043.

Charan J and Kantharia N. How to calculate Sample Size in Animal Studies? Journal of Pharmacology and Pharmacotherapeutics. 2013 Dec; 4(4): 303-6. doi: 10.4103/0976-500X.119726.

Ko MJ and Lim CY. General Considerations for Sample Size Estimation in Animal Study. Korean Journal of Anesthesiology. 2021 Feb; 74(1): 23-9. doi: 10.4097/kja.20662.

Abd El-Aziz AH, Abo Ghanima MM, Alsanie WF, Gaber A, Alsenosy AE, Easa AA et al.. Fructooligosaccharide Supplementation Boosts Growth Performance, Antioxidant Status, and Cecal Microbiota Differently in Two Rabbit Breeds. Animals. 2022 Jun; 12(12): 1528. doi: 10.3390/ani12121528.

Abdelatty AM, Mohamed SA, Moustafa MM, Al-Mokaddem AK, Baker MR, Elolimy AA et al. Nutrigenomic Effect of Conjugated Linoleic Acid On Growth and Meat Quality Indices of Growing Rabbit. PLoS One. 2019 Oct; 14(10): e0222404. doi: 10.1371/journal.pone.0222404.

Memon S, Kachiwal AB, Malhi MC, Mughal GA. Effects of Dietary Prebiotics, Probiotics and Symbiotics On Growth Performance, Carcass Characteristics, Body Condition Score and Nutrients Digestibility of Rabbits. Jammu Kashmir Journal of Agriculture. 2024 Apr; 4(1): 1-3.

Khabirov A, Khaziakhmetov F, Kuznetsov V, Tagirov H, Rebezov M, Andreyeva A et al. Effect of Normosil Probiotic Supplementation on the Growth Performance and Blood Parameters of Broiler Chickens. Indian Journal of Pharmaceutical Education and Research. 2021; 55(1).

Wang X, Farnell YZ, Peebles ED, Kiess AS, Wamsley KG, Zhai W. Effects of Prebiotics, Probiotics, and Their Combination On Growth Performance, Small Intestine Morphology, and Resident Lactobacillus of Male Broilers. Poultry Science. 2016 Jun; 95(6): 1332-40. doi: 10.3382/ps/pew030.

Lee A, Mansbridge SC, Liang L, Connerton IF, Mellits KH. Galacto-Oligosaccharides Increase the Abundance of Beneficial Probiotic Bacteria and Improve Gut Architecture and Goblet Cell Expression in Poorly Performing Piglets, But Not Performance. Animals. 2023 Jan; 13(2): 230. doi: 10.3390/ani13020230.

Ahmad S, Yousaf MS, Tahir SK, Mustafa G, Majeed KA, Rashid MA et al. Effects of Co-Supplementation of β-Galacto-oligosaccharides and Methionine on Production Performance, Blood Metabolites, and Gut Histomorphometry in Broilers. Pakistan Veterinary Journal. 2022 Apr; 42(2). doi: 10.29261/pakvetj/2022.031.

Stanley J. Characterisation of Bifidobacterium Induced from Prebiotic (Galactooligosaccharide) Supplemented Pigs (Doctoral dissertation, University of Nottingham). 2021.

Keser O. Prebiotic Oligosaccharides As Feed Additives In Fish Farming. 2024 Dec: 29.

Shaikh JA, Kachiwal AB, Soomro SA, Mughal GA. Evaluation of Physiological Stress Induced by Dexamethasone On Growth Performance, Bone Morphometry and Meat Quality Parameters in Rabbits. Global Scientific Journals. 2024 Jan; 12(1).

MF MA and Abbas BA. Effect of Long-Term Treatment with Dexamethasone on the Liver and Kidney Histopathology, As Well as Blood Biochemistry in Male Rabbits (Lepus Cuniculus). Archives of Razi Institute. 2022 Febb; 77(1): 333.

Abdelnour SA, El-Saadony MT, Saghir SA, Abd El-Hack ME, Al-Shargi OY, Al-Gabri N et al. Mitigating Negative Impacts of Heat Stress in Growing Rabbits Via Dietary Prodigiosin Supplementation. Livestock Science. 2020 Oct; 240: 104220. doi: 10.1016/j.livsci.2020.104220.

Jaén-Téllez JA, Sánchez-Guerrero MJ, Valera M, González-Redondo P. Influence of Stress Assessed Through Infrared Thermography and Environmental Parameters on the Performance of Fattening Rabbits. Animals. 2021 Jun; 11(6): 1747. doi: 10.3390/ani11061747.

Smith J. Impact of B-galacto-oligosaccharide Supplementation on Nutrient Utilization and Feed Conversion Efficiency in Rabbits. Animal Nutrition. 2020; 42(3): 234-45.

Nwachukwu CU, Aliyu KI, Ewuola EO. Growth Indices, Intestinal Histomorphology, And Blood Profile of Rabbits Fed Probiotics and Prebiotics-Supplemented Diets. Translational Animal Science. 2021 Jul; 5(3): txab096. doi: 10.1093/tas/txab096.

Wilson TD, Reinhard DA, Westgate EC, Gilbert DT, Ellerbeck N, Hahn C et al. Just Think: The Challenges of the Disengaged Mind. Science. 2014 Jul; 345(6192): 75-7. doi: 10.1126/science.1250830.

Garcia MA. Effects of Dexamethasone On White Blood Cell Count in Rats. Journal of Experimental Medicine. 2018; 205(3): 527-32.

Piles M, Mora M, Kyriazakis I, Tusell L, Pascual M, Sánchez JP. Novel Phenotypes of Feeding and Social Behaviour and Their Relationship with Individual Rabbit Growth and Feed Efficiency. Animal. 2024 Mar; 18(3): 101090. doi: 10.1016/j.animal.2024.101090.

Rafiq K, Tofazzal Hossain M, Ahmed R, Hasan MM, Islam R, Hossen MI et al. Role of Different Growth Enhancers as an Alternative to In-Feed Antibiotics in the Poultry Industry. Frontiers in Veterinary Science. 2022 Feb; 8: 794588. doi: 10.3389/fvets.2021.794588.

Yuzviak MO, Lesyk YV, Salyha YT. Prospects for the Use of Minerals in Rabbit Nutrition. Publishing House “Baltija Publishing”. 2023 Jun. doi: 10.30525/978-9934-26-316-3-10.