Effect of Screen Time on Biogenic Amines, Gross Behavior and Histological Conditions of Rat’s Brain : Effect of Screen Time on Rat’s Brain

Rabia Munawwar; Humaira Anser; Zunash Fatima; Rabeeya Rehman; Javeria Iftikhar; Sana Sarfraz; Kiran Rafiq

doi:10.54393/fbt.v4i01.104

Authors

Rabia Munawwar Department of Pharmacology, Faculty of Pharmacy, Jinnah Sindh Medical University, Karachi, Pakistan
Humaira Anser Department of Pharmacology, Faculty of Pharmacy, Jinnah Sindh Medical University, Karachi, Pakistan
Zunash Fatima Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
Rabeeya Rehman Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
Javeria Iftikhar Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan
Sana Sarfraz Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
Kiran Rafiq Department of Pharmaceutical Chemistry, Jinnah Sindh Medical University, Karachi, Pakistan

DOI:

https://doi.org/10.54393/fbt.v4i01.104

Keywords:

Screen Time, Biogenic Amines, Neurotransmitters, Histopathology, Dopamine Receptors

Abstract

Neurotransmitters and hormones work together in a complex way in the body to control mental and physical processes. Objective: To focus on dopamine, a crucial neurotransmitter produced by mesencephalic neurons in both the brain and peripheral organs. Methods: The study was conducted on albino rats weighing 180-200 gm. The rats were introduced into the new apparatus designed with the measurements of 40 x 40 cm in length, 25 x 25 cm in breadth, and 30 cm in height on all four sides. All sides were painted black except one mounted with (Light Emitted Diode) LED display. Rats were shown the screen for 1 hour daily for 30 minutes with high pixel resolutions and bright colors. The tested group was then compared with the control group on the 30th day on the parameters of gross behavior, biogenic amines of brains, and brain histopathology. Results: The results showed anxiety and hyperactive behavior in gross studies. Biogenic amines showed an increase in 2-amino 5-methyl benzoic acid that is the dopamine precursor. The study indicated that low levels of pyrrolidine, which decreased (Gamma Aminobutyric Acid) GABA in the brain, ultimately caused sleep disorders. Histopathological studies also showed the degeneration of neuronal cells in tested brains compared to control. Conclusions: The changes found in rats might be useful in determining the drawbacks of using mobiles, tabs, and other screen time

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