Therapeutic Interventional Probiotic Approach and the Treatment of Chronic Kidney Disease (CKD) Associated Uremia: Therapeutic Probiotic Approach and Chronic Kidney Disease Associated Uremia

Sahar Imran; Nofa Amjad; Zuha Sohail; Saba Gulnaz; Noor Fatima Azeem; Madiha Khan Niazi; Quratul Ain Shahid; Farooq Hassan; Muhammad Amjad Ismail; Wajeeda Abid

doi:10.54393/fbt.v5i3.187

Authors

Sahar Imran University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Nofa Amjad Teeside University, United Kingdom
Zuha Sohail University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Saba Gulnaz University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Noor Fatima Azeem Department of Dietetics, AimFit, Lahore, Pakistan
Madiha Khan Niazi University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Quratul Ain Shahid University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
Farooq Hassan Punjab Healthcare Commission, Lahore, Pakistan
Muhammad Amjad Ismail Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan
Wajeeda Abid Department of Eastern Medicine, Noor Puri Tibia College, Gojra, Pakistan

DOI:

https://doi.org/10.54393/fbt.v5i3.187

Keywords:

Chronic Kidney Disease, Intestinal Microbiome, Uremic Toxins Generation, Glomerular Filtration Rate

Abstract

Chronic kidney disease is a heterogeneous disorder characterized by progressive renal malfunction triggered by low Glomerular filtration rate (GFR) with increased morbidity and associated mortality. Intestinal microbiota dysbiosis has recently emerged as an important player in progressing chronic renal disease complications by increasing uremic toxins. Recently, the interest in developing new research initiatives focusing on therapeutic modulation of the intestinal microbiome through a probiotics approach, preserving kidney functionality by maintaining the physiological balance of intestinal microbiota, decreasing uremic toxins production, and improving the kidney-gut axis functionality has been considered as a comprehensive therapeutic approach in controlling and managing chronic kidney disease and associated complications within vitro or in vivo trial analysis. This review shed light on highlighting and exploring chronic kidney disease symptomatic triggers, uremic toxins generation and utilization of strain specified probiotic therapeutically approach exploring its significant efficiency through a wide range of randomized controlled trial analysis within chronic kidney disease patients (CKD) on HD and PD therapy which significantly reported low inflammatory biomarkers and improved dysregulated intestinal microbiota, increased uremic toxin excretion (IS and PCS), improved homeostatic regulatory mechanism and quantifies health furthermore delaying the progression towards kidney failure emerging probiotic approach as a new therapeutically CKD management tool.

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