Clinical Implication of Hepatic Phosphatases in Hyperthyroidism

Hepatic Phosphatases in Hyperthyroidism


  • Maria Fareed Siddiqui Centre for Research in Molecular Medicine, The University of Lahore, Pakistan
  • Muhammad Raza Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan
  • Muhammad Mohsin Aftab Institute of Public Health, Lahore, Pakistan



Hyperthyroidism, Thyroid Stimulating Hormone, Liver Function


Thyroid hormones significantly affect the proper growth, development and functioning of liver. It has been seen that the drugs indicated for thyroid abnormalities also cause troubles in liver function. Objective: To check the effect of thyroid abnormality on liver function. Methods: Patients were recruited from Center of Nuclear Medicine and examined for their thyroid status and liver functions. Results: The results obtained through biochemical tests for potential biomarkers were further explored through statistical analysis which showed the strong correlation between disturbed function of thyroid gland and liver working. Any variation in thyroid function brings change in liver functioning. Conclusions: Therefore, while treating thyroid patients, combination therapy must be recommended to effectively treat the associated disorder and increasing the better social and psychological status of the patient.  Furthermore, patients coming with thyroid dysfunction must also be examined for liver abnormalities so that culprit cause of this thyroid abnormality could be treated from the root if present.


Kester MH, Martinez de Mena R, Obregon MJ, Marinkovic D, Howatson A, Visser TJ, et al. Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. The Journal of Clinical Endocrinology & Metabolism. 2004 Jul; 89(7): 3117-28. doi: 10.1186/s12909-021-02846-x

Evans GR, Gherardini G, Gürlek A, Langstein H, Joly GA, Cromeens DM, et al. Drug-induced vasodilation in an in vitro and in vivo study: the effects of nicardipine, papaverine, and lidocaine on the rabbit carotid artery. Plastic and Reconstructive Surgery. 1997 Nov; 100(6): 1475-81. doi: 10.1016/S0140-6736(12)60560-1

Mulder JE. Thyroid disease in women. Medical Clinics of North America. 1998 Jan; 82(1): 103-25.

Goolsby MJ and Blackwell J. Evaluation and treatment of hyperthyroidism and hypothyroidism. Journal of the American Academy of Nurse Practitioners. 2004 Oct; 16(10): 422-5. doi: 10.1186/1471-2393-14-59

Cooper DS. Treatment of thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar’s the Thyroid, 7th edn. Philadelphia: Lippincott-Raven, 1996: 713–34.

Gürlek A, Çobankara V, Bayraktar M. Liver tests in hyperthyroidism: effect of antithyroid therapy. Journal of clinical gastroenterology. 1997 Apr; 24(3): 180-3. doi: 10.1016/j.ijgo.2004.07.001

Huang MJ, Li KL, Wei JS, Wu SS, Fan KD, Liaw YF. Sequential liver and bone biochemical changes in hyperthyroidism: prospective controlled follow-up study. American Journal of Gastroenterology (Springer Nature). 1994 Jul; 89(7): 1071-1076. doi: 10.3396/ijic.v18.21469

Kim HJ, Kim BH, Han YS, Yang I, Kim KJ, Dong SH, et al. The incidence and clinical characteristics of symptomatic propylthiouracil-induced hepatic injury in patients with hyperthyroidism: a single-center retrospective study. The American Journal of Gastroenterology. 2001 Jan; 96(1): 165-9.

Singer PA, Cooper DS, Daniels GH, Ladenson PW, Greenspan FS, Levy EG, et al. Treatment guidelines for patients with thyroid nodules and well-differentiated thyroid cancer. Archives of Internal Medicine. 1996 Oct; 156(19): 2165-72. doi: 10.1016/j.ijans.2019.05.001

Liaw YF, Huang MJ, Fan KD, Li KL, Wu SS, Chen TJ. Hepatic injury during propylthiouracil therapy in patients with hyperthyroidism: a cohort study. Annals of Internal Medicine. 1993 Mar; 118(6): 424-8.

Vitug AC and Goldman JM. Hepatotoxicity from antithyroid drugs. Hormone Research in Paediatrics. 1985 Nov; 21(4): 229-34.

Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid. 2012 Dec; 22(12): 1200-35. doi: 10.5958/0976-5506.2018.00101.8

Shen C, Zhao CY, Liu F, Wang YD, Yu J. Acute-on-chronic liver failure due to thiamazole in a patient with hyperthyroidism and trilogy of Fallot: case report. Bmc Gastroenterology. 2010 Dec; 10(1): 1-5. doi: 10.11604/pamj.2020.37.263.24628

Behroozi-Lak T, Akbary A, Vazifekhah S, Naghavi-Behzad M, Mirza-Aghazadeh-Attari M. Association of hypothyroidism and anti-thyroid antibodies with preterm delivery: a cross sectional study. Journal of Family & Reproductive Health. 2017 Dec; 11(4): 191.

Massie BM, Tierney LM, Mc Phee SJ, Papavaki MA. Current medical diagnosis and treatment. New York: Mc Graw-Hill. 2001. doi: 10.1186/s12978-019-0765-y

Akhter S, Khan A, Siddiqui MM, Nawab G. Frequencies of thyroid problems in different age, sex and seasons. Journal of Medical Sciences. 2001 May; 1: 153-6. doi: 10.1186/s12884-018-2059-8

Tibi L, Patrick AW, Leslie P, Toft AD, Smith AF. Alkaline phosphatase isoenzymes in plasma in hyperthyroidism. Clinical Chemistry. 1989 Jul; 35(7): 1427-30.

Boulanger L, Kim J, Friedman M, Hauch O, Foster T, Menzin J. Patterns of use of antithrombotic therapy and quality of anticoagulation among patients with non‐valvular atrial fibrillation in clinical practice. International Journal of Clinical Practice. 2006 Mar; 60(3): 258-64. doi: 10.1097/SIH.0b013e31819171cd

Einollahi B, Taghipour M, Motalebi M, Ramezani-Binabaj M. Normal alkaline phosphatase level in a patient with primary hyperparathyroidism due to parathyroid adenoma. Journal of Parathyroid Disease. 2014 Mar; 2(1): 47-50. doi: 10.1016/j.ijans.2021.100365

Aydemir S, Bayraktaroglu T, Demircan N, Sert M, Açikgoz S, Tekin IO, et al. Effect of hyperthyroidism and propylthiouracil treatment on liver biochemical tests. International Journal of Clinical Practice. 2005 Nov; 59(11): 1304-8.



DOI: 10.54393/fbt.v2i02.20
Published: 2022-12-31

How to Cite

Fareed Siddiqui, M., Raza, M., & Mohsin Aftab, M. (2022). Clinical Implication of Hepatic Phosphatases in Hyperthyroidism: Hepatic Phosphatases in Hyperthyroidism. Futuristic Biotechnology, 2(02), 02–06.



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