Assessing the Impact of Xenobiotic (Bisphenol A) on Blood Physiology and Biochemical Alterations Using Labeo Rohita Fish as a Model Organism: Impact of Bisphenol A on Blood Physiology in Labeo Rohita

Shabbir Ahmad; Hasnain Akmal; Khurram Shahzad

doi:10.54393/fbt.v4i02.122

Authors

Shabbir Ahmad Department of Zoology, University of Okara, Okara, Pakistan
Hasnain Akmal Department of Zoology, University of Okara, Okara, Pakistan
Khurram Shahzad Department of Zoology, University of Okara, Okara, Pakistan

DOI:

https://doi.org/10.54393/fbt.v4i02.122

Keywords:

Bisphenol A, Hematobiochemical, Labeo Rohita

Abstract

Bisphenol A (BPA) is an emerging pollutant that is extensively used in the manufacturing of various industrial products and is associated with adverse effects on both human and wildlife health. Objective: Present study aimed to evaluate the effects of bisphenol A on hematobiochemical biomarkers in freshwater Labeo rohita. Methods: For the purpose of this investigation, healthy fish were divided into four groups (A–D). Group A was treated as a BPA-free control group, while Group B, Group C, and Group D were exposed to various doses of BPA such as 400, 800, and 1600 µg/L, respectively for 21 days. Results: BPA-exposed fish showed different physical and behavioral abnormalities in dose-dependent ways. Results indicated significant increase in the concentrations of various hematobiochemical parameters, such as WBCs, MCHC, RDW, RDW-SD, platelets, neutrophils, triglycerides, cholesterol, ALT, AST, blood glucose, urea, T₃, TSH and creatinine, while HGB, RBCs, HCT, MCV, MCH, PDW, lymphocytes, HDL, LDL, VLDL, total protein, globulin, albumin and T₄ concentrations were decreased. Conclusions: The current study concluded that bisphenol A causes deleterious effects by disrupting physiological and hematobiochemical parameters alteration in exposed fish.

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